DoxyPEP Online

DoxyPEP Online is available by telehealth from anywhere in Australia through Clinic365. A Specialist GP consults with you by phone, arranges the appropriate treatment and sends your referral electronically to any pharmacy. No in-person visit is needed. The same expert care, from anywhere in Australia.

DoxyPEP (post-exposure prophylaxis) is a new prevention strategy that involves taking a single dose of antibiotics within 72 hours of condomless sex to reduce the risk of acquiring bacterial sexually transmitted infections. Clinical trials have shown that DoxyPEP reduces chlamydia acquisition by approximately 88 per cent, syphilis by 87 per cent, and gonorrhoea by approximately 55 per cent in men who have sex with men and transgender women.

The dosing protocol is straightforward. Take the prescribed dose within 24 to 72 hours after condomless sex. Do not exceed the prescribed dose in any 24-hour period, regardless of the number of sexual encounters. If you have sex on multiple consecutive days, take one dose daily. The medication is an inexpensive and widely available antibiotic with a well-established safety profile.

DoxyPEP is primarily recommended for populations with high rates of bacterial STIs, particularly men who have sex with men and transgender women. It is often used alongside PrEP as part of a comprehensive sexual health prevention strategy. Your Specialist GP will assess whether DoxyPEP is appropriate for your individual risk profile and sexual practices during your telehealth consultation.

An important consideration with DoxyPEP is the potential contribution to antibiotic resistance. This is an active area of research and surveillance. Current evidence suggests the benefits outweigh the risks for high-risk populations, but DoxyPEP should be prescribed by a knowledgeable clinician who can monitor for resistance patterns and adjust recommendations as evidence evolves.

DoxyPEP does not replace regular STI screening. Quarterly screening remains essential for all people using DoxyPEP, as it does not provide complete protection — particularly against gonorrhoea — and breakthrough infections can occur. It also does not protect against HIV, viral hepatitis, or herpes. Your Specialist GP will coordinate regular screening alongside your DoxyPEP treatment through Clinic365.

HIV and STI prevention strategies have advanced significantly in recent years, giving individuals more control over their sexual health than ever before. Your Specialist GP will assess your individual risk profile, discuss all available prevention options, and recommend the approach that best fits your lifestyle and sexual practices. Prevention is most effective when combined with regular screening — Clinic365 recommends a full STI screen at least every three months for individuals at higher risk.

All prevention through Clinic365 is PBS-eligible where applicable, keeping out-of-pocket costs low. Your GP will explain the dosing regimen, monitoring requirements, potential side effects, and what to do if you miss a dose or experience an exposure. Ongoing management is designed to be as simple as possible — with quarterly refills available for $39 online and pathology referrals sent by SMS. If your circumstances change or you have questions between appointments, telehealth consultations are available for $59.

Prevention is a core part of Clinic365's approach to sexual health. In addition to medication-based prevention, your Specialist GP can discuss comprehensive risk reduction strategies including condom use, regular screening schedules, vaccination against HPV and hepatitis, and harm reduction approaches. The goal is to empower you with the knowledge and tools to make informed decisions about your sexual health. Prevention consultations can be combined with routine STI screening, making it easy to address multiple aspects of your sexual health in a single appointment.